Organizational and activational effects of estrogenic endocrine disrupting chemicals

Organizational and activational effects of estrogenic endocrine disrupting chemicals.

Endocrine disruption is a hypothesis of common mode of action that may define a set of structurally varied chemicals, both natural and synthetic. Their common mode of action may suggest that they produce or contribute to similar toxic effects, although this has been difficult to demonstrate. Insights from developmental biology suggest that development of hormone sensitive systems, such as the b...

Effects of Endocrine Disrupting Chemicals on Seals

At the same time harbour porpoises, that had died of a similar virus, appeared stranded on the beaches. Two years later another mass die-off occurred in the Mediterranean striped dolphin populations. The severe and lethal outcomes of the epidemics led many in the scientific community to believe that a contaminantinduced immune deficiency was responsible for the high mortality during the epidemi...

Development of Plasma Vitellogenin Assay for Estrogenic Effects of Endocrine-Disrupting Chemicals Using Ovariectomized Goldfish

Endocrine disrupting chemicals

The idea that xenobiotic chemicals could inappropriately modlate the endocrine system thereby causing detrimental effects n wildlife and humans was first proposed 20 years ago at the atershed Wingspread Conference [1,2]. These endocrine disruptng chemicals (EDCs) have long been controversial, with a great eal of discussion raging in the scientific literature. Much of this ontroversy has centere...

Large effects from small exposures. I. Mechanisms for endocrine-disrupting chemicals with estrogenic activity.

Information concerning the fundamental mechanisms of action of both natural and environmental hormones, combined with information concerning endogenous hormone concentrations, reveals how endocrine-disrupting chemicals with estrogenic activity (EEDCs) can be active at concentrations far below those currently being tested in toxicological studies. Using only very high doses in toxicological stud...